Where Does Your Microbiome Come From?

08.12.20
Seed
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Your body is home to a diverse community of 38,000,000,000,000 (that’s 38 trillion!) microorganisms (1). Most of them reside in your gut, where they help aid in essential functions like digestion, immune response, and nutrient absorption. You’ll also find smaller communities in places like the mouth, skin, vagina, and penis.

Organs we once thought were sterile—the lungs, the eyes, the ears—are all teeming with distinct microbial life, too. Your body isn’t just an ecosystem; it’s a planet full of ecosystems! These microbes represents 50% of you by cell count, and collectively, their genes constitute your microbiome. But where did they come from, and how did they end up in (and on) your body?

To answer that question, we need to go back to the very beginning—your beginning.

Like your genome or your fingerprint, your microbiome is completely unique to you—the kaleidoscope of bacteria, fungi, viruses, and archaea that you harbor cannot be found anywhere else on earth. Unlike your genome, it is (mostly) passed down by a single parent.

Your microbiome, as it turns out, is mostly maternal in origin. It makes sense if you think about it. The first microbes you’re exposed to are your mother’s—through the birth canal, skin-to-skin contact, and breastfeeding (2).

The exposure to these foundational microbes is called seeding, and it continues to be influenced by the environment you’re born into. Nature, nutrition, family members, pets, and even the hospital room where you take your first breath can all contribute to your microbial mosaic.

By the age of two or three, your community of flora will stabilize into what’s called your steady state microbiome. External factors like diet, exercise, medicine, and sleep will continue to alter the composition for the rest of your life, but your dominant species should remain relatively unchanged, especially if you treat them well.

Seeding is an essential part of your early biological development. These first microbes colonize your gastrointestinal system and quickly reproduce, ensuring long term residency through strength in numbers. They also form the foundation of your immune system (3). Without them, your body wouldn’t know how to distinguish between benign (read: harmless) substances and pathogenic (read: harmful) invaders.

Translation? Immunity is not just innate—but also learned—and our microbiome plays a critical role in training our bodies to recognize threats. Performing that role well requires a healthy and diverse community of resident microbes. It also requires adequate exposure to a diverse range of microbes outside of our bodies (that’s a whole other story).

If your microbial community is compromised during the seeding process, the training of your immune system can be compromised too. In fact, scientists now believe that many allergic conditions and autoimmune diseases may stem from premature disruptions in microbiome development triggered by antibiotics, cesarean delivery, and even the use of infant formula (4).

Seeding clearly has significant implications for our long term health. That’s why it’s so important to identify the inputs and unravel the mechanisms involved. Fortunately, scientific understanding has come a long way in a very short amount of time, thanks to next generation tools like metagenome sequencing, and exploratory initiatives like the Human Microbiome Project.

Still, important questions remain:

Are there strains or species of bacteria that are particularly important for seeding?
Are there strains or species of bacteria that are detrimental? How exactly is seeding impacted by natural birth, versus cesarean birth?
How exactly is the microbiome impacted by natural breast milk vs. infant formula?
How exactly do antibiotics affect the seeding process? What about environmental disinfectants?


While additional research is necessary to answer these questions conclusively, preliminary data is already rushing in. In 2017, for instance, a team of scientists at UCLA found that 30% of the beneficial bacteria in a baby’s intestinal tract came from the mother’s breast milk, while an additional 10% came from the skin on the mother’s breast (5).

In 2018, a study of more than one million Swedish children found a positive link between cesarean delivery and food allergy risk (6). However, a separate study suggested that the microbiome-related disruptions associated with c-sections have less to do with the method of delivery, and more to do with the corresponding use of antibiotics, and related changes in breastfeeding behavior (7).

In 2019, scientists discovered that the maternal microbiome is actually reshaped during the late stages of pregnancy, presumably for the benefit of the fetus (8). Specifically, they found that progesterone—a hormone that prepares the body for conception, among other functions—has a direct effect on the richness of key bacterial genera, including Bifidobacterium.

Most recently, scientists confirmed that disruptions in the infant microbiome are contributing to the rise of food allergies by identifying a distinct ‘microbial signature’ in food allergic children that healthy children do not have (9). They were able to isolate bacterial strains that help protect against allergic reactions by activating a special group of immune cells to express a protein that halts immune response in the presence of harmless substances (read: allergens).

In the near future, that could mean targeted interventions (read: probiotics and fecal microbiota transplants) for those at highest risk of becoming food allergic—namely, infants whose parents or siblings suffer from allergic conditions like eczema (10), asthma (11), and food allergy (12). It could even lead to treatments for children and adults who already suffer from food allergies. And indeed, these are in the early stages of development as we speak.

Other treatments and interventions related to seeding are also in the works, though their efficacy is far from conclusive. One of the most compelling—and controversial—is vaginal swabbing, sometimes referred to as bacterial baptism. The practice involves swabbing cesarean-delivered babies with the mother’s vaginal fluids immediately after birth.

The idea is to expose them to the microbes they would otherwise ‘miss out’ on, in the hopes that they will colonize the infant. In 2016, a preliminary study showed that post-C-section exposure to vaginal fluids was able to partially restore newborns’ bacterial communities, though the sampling size and sampling efforts were limited (13). Meanwhile, a more recent study argued that vaginal swabbing is unjustified, and potentially even unsafe (14).

To sum up, answers are coming—and fast—but there’s a lot more work to be done.

The discovery of the microbiome marks an evolution of human (and women’s) health. New technologies and research inform us that we are vast, complex ecosystems—seeded first by our mothers, and sculpted further by the world around us. This new biology reveals the potential of bacteria to set ourselves—and our children—up for the healthiest life possible. By every indication, it won’t be long before that potential is unlocked.